The Therapeutically Relevant Multiple Pathways Database

The Therapeutically Relevant Multiple Pathways Database

   To facilitate mechanistic study of drug actions and a more comprehensive understanding the relationship between different targets of the same disease, it is useful to develop a database of known therapeutically relevant multiple pathways (TRMPs). The Therapeutically Relevant Multiple Pathways Database is designed to provide information about such multiple pathways and related therapeutic targets described in the literatures, the targeted disease conditions, and the corresponding drugs/ligands directed at each of these targets. This database currently contains 11 entries of multiple pathways, 97 entries of individual pathways, 120 targets covering 72 disease conditions along with 120 sets of drugs directed at each of these targets. Each entry can be retrieved through multiple methods including multiple pathway name, individual pathway name and disease name. Additional information provided include protein name, synonyms, Swissprot AC number, species, gene name and location, protein sequence (AASEQ) and gene sequence (NTSEQ) as well as potential therapeutic implications while applicable. Cross-links to other databases are provided which include Genecard, GDB, Locuslink, NCBI, KEGG, OMIM, SwissProt to facilitate the access of more detailed information about various aspects of the particular target or non-target protein.

This is the page that allows us to search the multiple pathways

Example of multiple pathway (Cardiovascular system related pathways)

   

  This database is very helpful as it provides information regarding multiple and single pathways along with related therapeutic targets, corresponding drugs/ligands, targeted disease conditions, constituent individual pathways, structural and functional information about each protein in the pathways. It also enable us to search for a disease along with its individual pathways. It gives us a clear picture about the disease and the sequences of the diseases. This is quite handy for the students, researchers and lecturers to find out details about the disease pathways. 

   For instance, I searched about cardiovascular system related pathways and it displays the pathways. The pathways are simple and nice to be read. Using different colours and arrows in the pathways causes the diagram attractive. Information such as protein names, synonyms, species, gene name and location, protein sequences and gene sequences. Information about these proteins and small molecules involved in these pathways also provides useful hint for searching new therapeutic targets.