Drug Adverse Reaction Target Database

An adverse drug reaction (ADR) is an injury caused by taking a medication. ADRs may occur following a single dose or prolonged administration of a drug or result from the combination of two or more drugs. The meaning of this expression differs from the meaning of "side effect", as this last expression might also imply that the effects can be beneficial.The study of ADRs is the concern of the field known as pharmacovigilance. An adverse drug event (ADE) refers to any injury occurring at the time a drug is used, whether or not it is identified as a cause of the injury. An ADR is a special type of ADE in which a causative relationship can be shown.

BIOINFORMATICS DATABASES

DRUG ADVERSE REACTION TARGET DATABASE

An adverse drug reaction (ADR) often results from interaction of a drug or its metabolites with specific protein targets important in normal cellular function. Knowledge about these targets is both important in facilitating the study of the mechanisms of ADRs and in new drug discovery. It is also useful in the development and testing of rational drug design and safety evaluation tools. The Drug Adverse Reaction Database (DART) is intended to provide comprehensive information about adverse effect targets of drugs described in the literature. Moreover, proteins involved in adverse effect targets of chemicals not yet confirmed as ADR targets are also included as potential targets. This database gives physiological function of each target, binding drugs/agonists/antagonists/activators/inhibitors, IC(50) values of the inhibitors, corresponding adverse effects, and type of ADR induced by drug binding to a target. Cross-links to other databases are also introduced to facilitate the access of information about the sequence, 3-dimensional structure, function, and nomenclature of each target along with drug/ligand binding properties, and related literature. The database currently contains entries for 147 ADR targets and 89 potential targets. A total of 187 adverse reaction conditions, 257 drugs, and 1080 ligands known to bind to each of these targets are also currently described. Each entry can be retrieved through multiple search methods including target name, target physiological function, adverse effect, ligand name, and biological pathways. A special page is provided for contribution of new or additional information.

BIOINFORMATICS AND DRUG DESIGN GROUP WEBSITE

A Database for facilitating the search for drug adverse reaction target. We can  find information about known drug adverse reaction targets,functions and properties

How to search informations in this website?
1.Query Methods
Queries can be submitted by entering the required information in any one or combination of the three fields in the form. All searching fields are case insensitive. Wild character of '*' and '?' is supported. '*' here represent a string of any length, and '?' represent any one character.


2.Target Name:
This search field accept both complete and incomplete name of protein target. For example, to find "Choline esterase", you can type either the full name of "Choline esterase" or its imcomplete name. Using imcomplete name search, all entries satisfy the query will be return. Searching with "choline" or "choline*" will match "ACETYLCHOLINE MUSCARINIC RECEPTOR", "ACETYLCHOLINE NICOTINIC RECEPTOR", "CHOLINESTERASE", and "BUTYRYLCHOLINESTERASE"; and searching with "Cholin?sterase" will match only "CHOLINESTERASE".


3.EC/SwissProt AC:
This field is exact match field. You must type in the exact EC number of enzyme or SwissProt Acess number. Wild character of '*' and '?' are NOT supported here. For example, enter EC number '3.1.1.7' or SwissProt access number 'P22303'will match 'Choline esterase' exactly.


4.Physilogical Function:
This field use the same searching method as Target Name. The Database will return all the entries which include the query keyword in their physiological function text.


5.Adverse Effect:
This field use the same searching method as Target Name. The Database will return all the entries which include the query keyword in their physiological function text.


6.Ligand:
This field use the same searching method as Target Name. The Database will return all the entries which include the query keyword in their physiological function text.

7.Pathway:
This field use the same searching method as Target Name. The Database will return all the entries which include the query keyword in their physiological function text.

 

Detailed Information of Choline Esterase Enzyme from BIDD Website

Another example of target enzyme : Dihydrofolate reductase